publications
Publications 2023:
Vahedi-Shahandashti R, Houbraken J, Birch M, Lass-Flörl C.: Novel Antifungals and Aspergillus Section Terrei with Potpourri Susceptibility Profiles to Conventional Antifungals.
J Fungi (Basel). 2023 Jun 6;9(6):649. doi: 10.3390/jof9060649.Vahedi-Shahandashti R, Hahn L, Houbraken J, Lass-Flörl C.: Aspergillus Section Terrei and Antifungals: From Broth to Agar-Based Susceptibility Testing Methods. J Fungi (Basel). 2023 Feb 27;9(3):306. doi: 10.3390/jof9030306.
Happacher I, Aguiar M, Alilou M, Abt B, Baltussen TJH, Decristoforo C, Melchers WJG, Haas H.: The Siderophore Ferricrocin Mediates Iron Acquisition in Aspergillus fumigatus.
Microbiol Spectr. 2023 Jun 15;11(3):e0049623. doi: 10.1128/spectrum.00496-23. Epub 2023 May 18.Gehrer CM, Mitterstiller AM, Grubwieser P, Meyron-Holtz EG, Weiss G, Nairz M.: Advances in Ferritin Physiology and Possible Implications in Bacterial Infection. Int J Mol Sci. 2023 Feb 28;24(5):4659. doi: 10.3390/ijms24054659.
De Souza LV, Hoffmann A, Fischer C, Petzer V, Asshoff M, Theurl I, Tymoszuk P, Seifert M, Brigo N, Hilbe R, Demetz E, Von Raffay L, Berger S, Barros-Pinkelnig M, Weiss G.: Comparative analysis of oral and intravenous iron therapy in rat models of inflammatory anemia and iron deficiency.
Haematologica. 2023 Jan 1;108(1):135-149. doi: 10.3324/haematol.2022.281149.Yap A, Volz R, Paul S, Moye-Rowley WS, Haas H.: Regulation of High-Affinity Iron Acquisition, Including Acquisition Mediated by the Iron Permease FtrA, Is Coordinated by AtrR, SrbA, and SreA in Aspergillus fumigatus. mBio. 2023 Jun 27;14(3):e0075723. doi: 10.1128/mbio.00757-23. Epub 2023 Apr 24.
Happacher I, Aguiar M, Alilou M, Abt B, Baltussen TJH, Decristoforo C, Melchers WJG, Haas H.: The Siderophore Ferricrocin Mediates Iron Acquisition in Aspergillus fumigatus.
Microbiol Spectr. 2023 Jun 15;11(3):e0049623. doi: 10.1128/spectrum.00496-23. Epub 2023 May 18.Happacher I, Aguiar M, Yap A, Decristoforo C, Haas H.: Fungal siderophore metabolism with a focus on Aspergillus fumigatus: impact on biotic interactions and potential translational applications. Essays Biochem. 2023 Jun 14:EBC20220252. doi: 10.1042/EBC20220252. Epub ahead of print. PMID: 37313590.
Publications 2022:
Vahedi-Shahandashti R, Dietl AM, Binder U, Nagl M, Würzner R, Lass-Flörl C.: Aspergillus terreus and the Interplay with Amphotericin B: from Resistance to Tolerance?
Antimicrob Agents Chemother. 2022 Apr 19;66(4):e0227421. doi: 10.1128/aac.02274-21. Epub 2022 Mar 7.Koller A, Brandl C, Lamina C, Zimmermann ME, Summerer M, Stark KJ, Würzner R, Heid IM, Kronenberg F.: Relative Telomere Length Is Associated With Age-Related Macular Degeneration in Women. Invest Ophthalmol Vis Sci. 2022 May 2;63(5):30. doi: 10.1167/iovs.63.5.30.
Kheirkhah A, Lamina C, Kollerits B, Schachtl-Riess JF, Schultheiss UT, Forer L, Sekula P, Kotsis F, Eckardt KU, Kronenberg F; GCKD Investigators.: PCSK9 and Cardiovascular Disease in Individuals with Moderately Decreased Kidney Function.
Clin J Am Soc Nephrol. 2022 Jun;17(6):809-818. doi: 10.2215/CJN.01230122. Epub 2022 Apr 6.Kakar A, Sastré-Velásquez LE, Hess M, Galgóczy L, Papp C, Holzknecht J, Romanelli A, Váradi G, Malanovic N, Marx F.: The Membrane Activity of the Amphibian Temporin B Peptide Analog TB_KKG6K Sheds Light on the Mechanism That Kills Candida albicans. mSphere. 2022 Aug 16:e0029022. doi: 10.1128/msphere.00290-22. Epub ahead of print.
Aguiar M, Orasch T, Shadkchan Y, Caballero P, Pfister J, Sastré-Velásquez LE, Gsaller F, Decristoforo C, Osherov N, Haas H.: Uptake of the Siderophore Triacetylfusarinine C, but Not Fusarinine C, Is Crucial for Virulence of Aspergillus fumigatus.
mBio. 2022 Sep 20:e0219222. doi: 10.1128/mbio.02192-22. Epub ahead of print.Sastré-Velásquez LE, Dallemulle A, Kühbacher A, Baldin C, Alcazar-Fuoli L, Niedrig A, Müller C, Gsaller F.: The fungal expel of 5-fluorocytosine derived fluoropyrimidines mitigates its antifungal activity and generates a cytotoxic environment. PLoS Pathog. 2022 Dec 27;18(12):e1011066. doi: 10.1371/journal.ppat.1011066.
De Souza LV, Hoffmann A, Fischer C, Petzer V, Asshoff M, Theurl I, Tymoszuk P, Seifert M, Brigo N, Hilbe R, Demetz E, Von Raffay L, Berger S, Barros-Pinkelnig M, Weiss G.: Comparative analysis of oral and intravenous iron therapy in rat models of inflammatory anemia and iron deficiency.
Haematologica. 2023 Jan 1;108(1):135-149. doi: 10.3324/haematol.2022.281149.Lackner N, Thomé C, Öfner D, Joannidis M, Mayerhöfer T, Arora R, Samardzic E, Posch W, Breitkopf R, Lass-Flörl C.: COVID-19 Associated Pulmonary Aspergillosis: Diagnostic Performance, Fungal Epidemiology and Antifungal Susceptibility. J Fungi (Basel). 2022 Jan 18;8(2):93. doi: 10.3390/jof8020093.
Bauer I, Abt B, Yap A, Leuchtle B, Haas H.: Online Biomass Monitoring Enables Characterization of the Growth Pattern of Aspergillus fumigatus in Liquid Shake Conditions.
J Fungi (Basel). 2022 Sep 27;8(10):1013. doi: 10.3390/jof8101013.
Publications 2021:
Kheirkhah A, Lamina C, Rantner B, Kollerits B, Stadler M, Pohlhammer J, Klein-Weigel P, Fraedrich G, Kronenberg F.: Elevated levels of serum PCSK9 in male patients with symptomatic peripheral artery disease: The CAVASIC study.
Atherosclerosis. 2021 Jan;316:41-47. doi: 10.1016/j.atherosclerosis.2020.11.025.Fazzini F, Lamina C, Raftopoulou A, Koller A, Fuchsberger C, Pattaro C, Del Greco FM, Döttelmayer P, Fendt L, Fritz J, Meiselbach H, Schönherr S, Forer L, Weissensteiner H, Pramstaller PP, Eckardt KU, Hicks AA, Kronenberg F; GCKD Investigators.: Association of mitochondrial DNA copy number with metabolic syndrome and type 2 diabetes in 14,176 individuals. J Intern Med. 2021 Jan 16. doi: 10.1111/joim.13242.
Rocamora-Reverte L, Melzer FL, Würzner R, Weinberger B.: The Complex Role of Regulatory T Cells in Immunity and Aging.
Front Immunol. 2021 Jan 27;11:616949. doi: 10.3389/fimmu.2020.616949.Malekshahi Z, Bernklau S, Schiela B, Koske B, Banki Z, Stiasny K, Harris CL, Würzner R, Stoiber H.: Incorporation of CD55 into the Zika Viral Envelope Contributes to Its Stability against Human Complement. Viruses. 2021; 13:510. doi:10.3390/v13030510.
Weissensteiner H, Forer L, Fendt L, Kheirkhah A, Salas A, Kronenberg F, Schoenherr S.: Contamination detection in sequencing studies using the mitochondrial phylogeny.
Genome Res. 2021 Jan 15;31(2):309-16. doi: 10.1101/gr.256545.119.Rosbjerg A, Würzner R, Garred P, Skjoedt MO.: MASP-1 and MASP-3 Bind Directly to Aspergillus fumigatus and Promote Complement Activation and Phagocytosis J Innate Immun. 2021; 29:1-14. doi: 10.1159/000514546.
Huber S, Knoll MA, Berktold M, Würzner R, Brindlmayer A, Weber V, Posch AE, Mrazek K, Lepuschitz S, Ante M, Beisken S, Orth-Höller D, Weinberger J.: Genomic and Phenotypic Analysis of Linezolid-Resistant Staphylococcus epidermidis in a Tertiary Hospital in Innsbruck, Austria.
Microorganisms 2021;9(5):1023. doi: 10.3390/microorganisms9051023.Pichler D, Baumgartner M, Kimpel J, Rössler A, Riepler L, Bates K, Fleischer V, von Laer D, Borena W, Würzner R.: Marked increase in avidity of Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) antibodies 7-8 months after infection is not diminished in old age. J Infect Dis. 2021 Jun 4:jiab300. doi: 10.1093/infdis/jiab300. Epub ahead of print.
Maio SD, Lamina C, Coassin S, Forer L, Würzner R, Schönherr S, Kronenberg F.: Lipoprotein(a) and SARS-CoV-2 infections: susceptibility to infections, ischemic heart disease and thromboembolic events.
J Intern Med. 2021 Jun 7:10.1111/joim.13338. doi: 10.1111/joim.13338. Epub ahead of print.Medeiros PMC, Schjalm C, Christiansen D, Sokolova M, Pischke SE, Würzner R, Mollnes TE, Barratt-Due A.: Vitamin C, Hydrocortisone and The Combination Thereof Significantly Inhibited Two of Nine Inflammatory Markers Induced by Escherichia Coli but not by Staphylococcus Aureus - When Incubated in Human Whole Blood. Shock. 2021 Jul 8. doi: 10.1097/SHK.0000000000001834. Epub ahead of print.
Huber S, Massri M, Grasse M, Fleischer V, Kellnerová S, Harpf V, Knabl L, Knabl L Sr, Heiner T, Kummann M, Neurauter M, Rambach R, Speth C, Würzner R.: Systemic Inflammation and Complement Activation Parameters Predict Clinical Outcome of Severe SARS-CoV-2 Infections.
Viruses. 2021 Nov 26;13(12):2376. doi: 10.3390/v13122376.Schachtl-Riess JF, Coassin S, Lamina C, Demetz E, Streiter G, Hilbe R, Kronenberg F.: Lysis reagents, cell numbers, and calculation method influence high-throughput measurement of HDL-mediated cholesterol efflux capacity. J Lipid Res. 2021;62:100125. doi: 10.1016/j.jlr.2021.100125.
Schachtl-Riess JF, Kheirkhah A, Grüneis R, Di Maio S, Schoenherr S, Streiter G, Losso JL, Paulweber B, Eckardt KU, Köttgen A, Lamina C, Kronenberg F, Coassin S; GCKD Investigators.: Frequent LPA KIV-2 Variants Lower Lipoprotein(a) Concentrations and Protect Against Coronary Artery Disease.
J Am Coll Cardiol. 2021 Aug 3;78(5):437-449. doi: 10.1016/j.jacc.2021.05.037.Haschka D, Tymoszuk P, Petzer V, Hilbe R, Heeke S, Dichtl S, Skvortsov S, Demetz E, Berger S, Seifert M, Mitterstiller AM, Moser P, Bumann D, Nairz M, Theurl I, Weiss G.: Ferritin H deficiency deteriorates cellular iron handling and worsens Salmonella typhimurium infection by triggering hyperinflammation. JCI Insight. 2021 Jul 8;6(13):e141760. doi: 10.1172/jci.insight.141760.
Lackner N, Vahedi-Shahandashti R, Jähnig S, Schönherr L, Lass-Flörl C.: Echinocandins and Their Activity against Aspergillus terreus Species Complex: a Novel Agar Screening Method.
Antimicrob Agents Chemother. 2022 Feb 15;66(2):e0190921. doi: 10.1128/AAC.01909-21. Epub 2021 Dec 13.Luvanda MK, Posch W, Vosper J, Zaderer V, Noureen A, Lass-Flörl C, Wilflingseder D.: Dexamethasone Promotes Aspergillus fumigatus Growth in Macrophages by Triggering M2 Repolarization via Targeting PKM2. J Fungi (Basel). 2021 Jan 20;7(2):70. doi: 10.3390/jof7020070.
Luvanda MK, Posch W, Noureen A, Lafon E, Zaderer V, Lass-Flörl C, Wilflingseder D.: Dexamethasone Creates a Suppressive Microenvironment and Promotes Aspergillus fumigatus Invasion in a Human 3D Epithelial/Immune Respiratory Model.
J Fungi (Basel). 2021 Mar 18;7(3):221. doi: 10.3390/jof7030221.Hofer J, Riedl Khursigara M, Perl M, Giner T, Rosales A, Cortina G, Waldegger S, Jungraithmayr T, Würzner R.: Early relapse rate determines further relapse risk: results of a 5-year follow-up study on pediatric CFH-Ab HUS. Pediatr Nephrol. 2021 Apr;36(4):917-925. doi: 10.1007/s00467-020-04751-9. Epub 2020 Oct 7.
Brigo N, Pfeifhofer-Obermair C, Tymoszuk P, Demetz E, Engl S, Barros-Pinkelnig M, Dichtl S, Fischer C, Valente De Souza L, Petzer V, von Raffay L, Hilbe R, Berger S, Seifert M, Schleicher U, Bogdan C, Weiss G.: Cytokine-Mediated Regulation of ARG1 in Macrophages and Its Impact on the Control of Salmonella enterica Serovar Typhimurium Infection.
Cells. 2021 Jul 19;10(7):1823. doi: 10.3390/cells10071823.Kakar A, Holzknecht J, Dubrac S, Gelmi ML, Romanelli A, Marx F.: New Perspectives in the Antimicrobial Activity of the Amphibian Temporin B: Peptide Analogs Are Effective Inhibitors of Candida albicans Growth. J Fungi (Basel). 2021 Jun 7;7(6):457. doi: 10.3390/jof7060457.
Aguiar M, Orasch T, Misslinger M, Dietl AM, Gsaller F, Haas H.: The Siderophore Transporters Sit1 and Sit2 Are Essential for Utilization of Ferrichrome-, Ferrioxamine- and Coprogen-Type Siderophores in Aspergillus fumigatus.
J Fungi (Basel). 2021 Sep 16;7(9):768. doi: 10.3390/jof7090768.
Publications 2020:
Deshmukh H, Rambach G, Sheppard DC, Lee M, Hagleitner M, Hermann M, Würzner R, Lass-Flörl C, Speth C.: Galactosaminogalactan secreted from Aspergillus fumigatus and Aspergillus flavus induces platelet activation.
Microbes Infect. 2020 Sep;22(8):331-339. doi: 10.1016/j.micinf.2019.12.004.Harpf V, Rambach G, Würzner R, Lass-Flörl C, Speth C.: Candida and Complement: New Aspects in an Old Battle. Front Immunol. 2020 Jul 14;11:1471. doi: 10.3389/fimmu.2020.01471.
Hofer J, Riedl Khursigara M, Perl M, Giner T, Rosales A, Cortina G, Waldegger S, Jungraithmayr T, Würzner R.: Early relapse rate determines further relapse risk: results of a 5-year follow-up study on pediatric CFH-Ab HUS.
Pediatr Nephrol. 2020 Oct 7. doi: 10.1007/s00467-020-04751-9.Deshmukh H, Speth C, Sheppard DC, Neurauter M, Würzner R, Lass-Flörl C, Rambach G.: Aspergillus-Derived Galactosaminogalactan Triggers Complement Activation on Human Platelets. Front Immunol. 2020 Oct 6;11:550827. doi: 10.3389/fimmu.2020.550827.
Malekshahi Z, Schiela B, Bernklau S, Banki Z, Würzner R, Stoiber H.: Interference of the Zika Virus E-Protein With the Membrane Attack Complex of the Complement System.
Front Immunol. 2020 Oct 28;11:569549. doi: 10.3389/fimmu.2020.569549. eCollection 2020.Kellnerová S, Chatterjee S, Bayarri-Olmos R, Justesen L, Talasz H, Posch W, Kenno S, Garred P, Orth-Höller D, Grasse M, Würzner R.: Shiga Toxin 2a Binds to Complement Components C3b and C5 and Upregulates Their Gene Expression in Human Cell Lines. Toxins (Basel). 2020 Dec 24;13(1):E8. doi: 10.3390/toxins13010008.
Pahlow S, Orasch T, Žukovskaja O, Bocklitz T, Haas H, Weber K.: Rapid detection of the aspergillosis biomarker triacetylfusarinine C using interference-enhanced Raman spectroscopy.
Anal Bioanal Chem. 2020 Sep;412(24):6351-6360. doi: 10.1007/s00216-020-02571-2.Dietl AM, Binder U, Bauer I, Shadkchan Y, Osherov N, Haas H.: Arginine Auxotrophy Affects Siderophore Biosynthesis and Attenuates Virulence of Aspergillus fumigatus. Genes (Basel). 2020 Apr 15;11(4):423. doi: 10.3390/genes11040423.
Yap A, Misslinger M, Haas H.: Absent regulation of iron acquisition by the copper regulator Mac1 in A. fumigatus.
Biochem J. 2020 Aug 28;477(16):2967-2970. doi: 10.1042/BCJ20200286.Demetz E, ..., Volani C, ..., Petzer V, ..., Dichtl S, Seifert M, von Raffay L, Fischer C, Barros-Pinkelnig M, Brigo N, Valente de Souza L, ..., Kronenberg F, Theurl I, Tancevski I, Weiss G.: The haemochromatosis gene Hfe and Kupffer cells control LDL cholesterol homeostasis and impact on atherosclerosis development. Eur Heart J. 2020 Oct 21;41(40):3949-3959. doi: 10.1093/eurheartj/ehaa140.
Fazzini F, Lamina C, Raschenberger J, Schultheiss UT, Kotsis F, Schönherr S, Weissensteiner H, Forer L, Steinbrenner I, Meiselbach H, Bärthlein B, Wanner C, Eckardt KU, Köttgen A, Kronenberg F; GCKD Investigators.: Results from the German Chronic Kidney Disease (GCKD) study support association of relative telomere length with mortality in a large cohort of patients with moderate chronic kidney disease
Kidney Int. 2020 Aug;98(2):488-497. doi: 10.1016/j.kint.2020.02.034.Haschka D, Tymoszuk P, Bsteh G, Petzer V, Berek K, Theurl I, Berger T, Weiss G.: Expansion of Neutrophils and Classical and Nonclassical Monocytes as a Hallmark in Relapsing-Remitting Multiple Sclerosis. Front Immunol. 2020 Apr 29;11:594. doi: 10.3389/fimmu.2020.00594.
Nairz M, Metzendorf C, Vujic-Spasic M, Mitterstiller AM, Schroll A, Haschka D, Hoffmann A, Von Raffay L, Sparla R, Huck CW, Talasz H, Moser PL, Muckenthaler MU, Weiss G.: Cell-specific expression of Hfe determines the outcome of Salmonella enterica serovar Typhimurium infection in mice.
Haematologica. 2020 Oct 13;Online ahead of print. doi: 10.3324/haematol.2019.241745.Tymoszuk P, Nairz M, Brigo N, Petzer V, Heeke S, Kircher B, Hermann-Kleiter N, Klepsch V, Theurl I, Weiss G, Pfeifhofer-Obermair C.: Iron Supplementation Interferes With Immune Therapy of Murine Mammary Carcinoma by Inhibiting Anti-Tumor T Cell Function. Front Oncol. 2020 Dec 4;10:584477. doi: 10.3389/fonc.2020.584477.
Vahedi-Shahandashti R, Lass-Flörl C.: Novel Antifungal Agents and Their Activity against Aspergillus Species.
J Fungi (Basel). 2020 Oct 9;6(4):213. doi: 10.3390/jof6040213.Pangrazzi L, Naismith E, Miggitsch C, Carmona Arana JA, Keller M, Grubeck-Loebenstein B, Weinberger B.: The impact of body mass index on adaptive immune cells in the human bone marrow. Immun Ageing. 2020 May 27;17:15. doi: 10.1186/s12979-020-00186-w.
Publications 2019:
Miggitsch C, Meryk A, Naismith E, Pangrazzi L, Ejaz A, Jenewein B, Wagner S, Nägele F, Fenkart G, Trieb K, Zwerschke W, Grubeck-Loebenstein B.: Human bone marrow adipocytes display distinct immune regulatory properties.
EBioMedicine 2019. doi: 10.1016/ j.ebiom.2019.07.023. [Epub ahead of print]Fazzini F, Lamina C, Fendt L, Schultheiss UT, Kotsis F, Hicks AA, Meiselbach H, Weissensteiner H, Forer L, Krane V, Eckardt KU, Köttgen A, Kronenberg F; and the GCKD Investigators.: Mitochondrial DNA copy number is associated with mortality and infections in a large cohort of patients with chronic kidney disease. Kidney International 96. doi: https://doi.org/10.1016/ j.kint.2019.04.021.
Brigotti M, Orth-Höller D, Carnicelli D, Porcellini E, Galassi E, Tazzari PL, Ricci F, Manoli F, Manet I, Talasz H, Lindner HH, Speth C, Erbeznik T, Fuchs S, Posch W, Chatterjee S, Würzner R.: The structure of the Shiga toxin 2a A-subunit dictates the interactions of the toxin with blood components.
Cell Microbiol. 2019 May;21(5):e13000. doi: 10.1111/cmi.13000.Kenno S, Speth C, Rambach G, Binder U, Chatterjee S, Caramalho R, Haas H, Lass-Flörl C, Shaughnessy J, Ram S, Gow NAR, Orth-Höller D, Würzner R.: Candida albicans Factor H Binding Molecule Hgt1p - A Low Glucose-Induced Transmembrane Protein Is Trafficked to the Cell Wall and Impairs Phagocytosis and Killing by Human Neutrophils. Front Microbiol. 2019 Jan 15;9:3319. doi: 10.3389/fmicb.2018.03319.
Dichtl S, Demetz E, Haschka D, Tymoszuk P, Petzer V, Nairz M, Seifert M, Hoffmann A, Brigo N, Würzner R, Theurl I, Karlinsey JE, Fang FC, Weiss G.: Dopamine Is a Siderophore-Like Iron Chelator That Promotes Salmonella enterica Serovar Typhimurium Virulence in Mice.
mBio. 2019 Feb 5;10(1):e02624-18. doi: 10.1128/mBio.02624-18.Hetzer B, Orth-Höller D, Würzner R, Kreidl P, Lackner M, Müller T, Knabl L, Geisler-Moroder DR, Mellmann A, Sesli Ö, Holzknecht J, Noce D, Boonpala O, Akarathum N, Chotinaruemol S, Prelog M, Oberdorfer P.: Enhanced acquisition of antibiotic-resistant intestinal E. coli during the first year of life assessed in a prospective cohort study. Antimicrob Resist Infect Control. 2019 May 20;8:79. doi: 10.1186/s13756-019-0522-6.
Sass G, Ansari SR, Dietl AM, Déziel E, Haas H, Stevens DA.: Intermicrobial interaction: Aspergillus fumigatus siderophores protect against competition by Pseudomonas aeruginosa.
PLoS One. 2019 May 8;14(5):e0216085. doi: 10.1371/journal.pone.0216085.Petzer V, Wermke M, Tymoszuk P, Wolf D, Seifert M, Ovaçin R, Berger S, Orth-Höller D, Loacker L, Weiss G, Haas H, Platzbecker U, Theurl I.: Enhanced labile plasma iron in hematopoietic stem cell transplanted patients promotes Aspergillus outgrowth. Blood Adv. 2019 Jun 11;3(11):1695-1700. doi: 10.1182/bloodadvances.2019000043.
Orasch T, Dietl AM, Shadkchan Y, Binder U, Bauer I, Lass-Flörl C, Osherov N, Haas H.: The leucine biosynthetic pathway is crucial for adaptation to iron starvation and virulence in Aspergillus fumigatus.
Virulence. 2019 Dec;10(1):925-934. doi: 10.1080/21505594.2019.1682760.Bauer I, Misslinger M, Shadkchan Y, Dietl AM, Petzer V, Orasch T, Abt B, Graessle S, Osherov N, Haas H.: The Lysine Deacetylase RpdA Is Essential for Virulence in Aspergillus fumigatus. Front Microbiol. 2019 Dec 4;10:2773. doi: 10.3389/fmicb.2019.02773.
Steger M, Bermejo-Jambrina M, Yordanov T, Wagener J, Brakhage AA, Pittl V, Huber LA, Haas H, Lass-Flörl C, Posch W, Wilflingseder D.: ?-1,3-glucan-lacking Aspergillus fumigatus mediates an efficient antifungal immune response by activating complement and dendritic cells.
Virulence. 2019 Dec;10(1):957-969. doi: 10.1080/21505594.2018.1528843.Pangrazzi L, Reidla J, Carmona Arana JA, Naismith E, Miggitsch C, Meryk A, Keller M, Krause AAN, Melzer FL, Trieb K, Schirmer M, Grubeck-Loebenstein B, Weinberger B.: CD28 and CD57 define four populations with distinct phenotypic properties within human CD8 + T cells. Eur J Immunol. 2020 Mar;50(3):363-379. doi: 10.1002/eji.201948362.
Naismith E, Pangrazzi L, Grasse M, Keller M, Miggitsch C, Weinberger B, Trieb K, Grubeck-Loebenstein B.: Peripheral antibody concentrations are associated with highly differentiated T cells and inflammatory processes in the human bone marrow.
Immun Ageing. 2019 Aug 22;16:21. doi: 10.1186/s12979-019-0161-z.Brini Khalifa I, Hannachi N, Guerrero A, Orth-Höller D, Bhiri S, Bougila J, Boughamoura L, Merchaoui SN, Sboui H, Mahdhaoui N, Schiela B, Laer DH, Boukadida J, Stoiber H.: Demographic and seasonal characteristics of respiratory pathogens in neonates and infants aged 0 to 12 months in the Central-East region of Tunisia. J Med Virol. 2019 Apr;91(4):570-581. doi: 10.1002/jmv.25347.
Publications 2018:
Grasse M, Meryk A, Miggitsch C, Grubeck-Loebenstein B.: GM-CSF improves the immune response to the diphtheria-component in a multivalent vaccine.
Vaccine 36 (31). doi: 10.1016/j.vaccine.2018.06.033.Dichtl S, Haschka D, Nairz M, Seifert M, Volani C, Lutz O, Weiss G.: Dopamine promotes cellular iron accumulation and oxidative stress responses in macrophages. Biochemical Pharmacology 148:193-201. doi: 10.1016/j.bcp.2017.12.001.
Coraça-Huber DC, Dichtl S, Steixner S, Nogler M, Weiss G.: Iron chelation destabilizes bacterial biofilms and potentiates the antimicrobial activity of antibiotics against coagulase-negative Staphylococci.
Pathogens and Disease 76 (5). doi: 10.1093/femspd/fty052.Grasse M, Rosenkrands I, Olsen A, Follmann F, Dietrich J.: A flow cytometry-based assay to determine the phagocytic activity of both clinical and nonclinical antibody samples against Chlamydia trachomatis. Cytometry A 93(5). doi: 10.1002/cyto.a.23353.
Hoenigl M, Orasch T, Faserl K, Prattes J, Loeffler J, Springer J, Gsaller F, Reischies F, Duettmann W, Raggam RB, Lindner H, Haas H.: Triacetylfusarinine C: A urine biomarker for diagnosis of invasive aspergillosis
Journal of Infection. doi: 10.1016/j.jinf.2018.09.006.Knabl L, Berktold M, Hamad OA, Fromell K, Chatterjee S, Speth C, Talasz H, Lindner K, Hermann M, Nilsson-Ekdahl K, Nilsson B, Streif W, Martini J, Würzner R, Orth-Höller D.: Shiga toxin 2a binds antithrombin and heparin, but does not directly activate platelets International Journal of Medical Microbiology 308(7). doi: 10.1016/j.ijmm.2018.07.008.
Jahreis S, Böttcher S, Hartung S, Rachow T, Rummler S, Dietl AM, Haas H, Walther G, Hochhaus A, von Lilienfeld-Toal M.: Human MAIT cells are rapidly activated by Aspergillus spp. in an APC-dependent manner.
European Journal of Immunology 48(10). doi: 10.1002/eji.201747312.Dietl AM, Meir Z, Shadkchan Y, Osherov N, Haas H.: Riboflavin and pantothenic acid biosynthesis are crucial for iron homeostasis and virulence in the pathogenic mold Aspergillus fumigatus. Virulence 9(1). doi: 10.1080/21505594.2018.1482181.
Kurucz V, Krüger T, Antal K, Dietl AM, Haas H, Pócsi I, Kniemeyer O, Emri T.: Additional oxidative stress reroutes the global response of Aspergillus fumigatus to iron depletion.
BMC Genomics 19(1). doi: 10.1186/s12864-018-4730-x.Dietl AM, Binder U, Shadkchan Y, Osherov N, Haas H.: Siroheme Is Essential for Assimilation of Nitrate and Sulfate as Well as Detoxification of Nitric Oxide but Dispensable for Murine Virulence of Aspergillus fumigatus. Frontiers in microbiology 9 (2615). doi: 10.3389/fmicb.2018.02615.
Kronenberg F.: HDL in CKD-The Devil Is in the Detail.
J Am Soc Nephrol 29(5). doi:10.1681/ASN.2017070798.Fazzini F, Schöpf B, Blatzer M, Coassin S, Hicks AA, Kronenberg F and Fendt L.: Plasmid-normalized quantification of relative mitochondrial DNA copy number. Scientific Reports 8:15347. doi:10.1038/s41598-018-33684-5.
Haschka D, Volani C, Stefani A, Tymoszuk P, Mitterling T, Holzknecht E, Heidbreder A, Coassin S, Sumbalova Z, Seifert M, Dichtl S, Theurl I, Gnaiger E, Kronenberg F, Frauscher B, Högl B, Weiss G.: Association of mitochondrial iron deficiency and dysfunction with idiopathic restless legs syndrome.
Mov Disord. 2019 Jan;34(1):114-123. doi: 10.1002/mds.27482.Long N, Orasch T, Zhang S, Gao L, Xu X, Hortschansky P, Ye J, Zhang F, Xu K, Gsaller F, Straßburger M, Binder U, Heinekamp T, Brakhage AA, Haas H, Lu L.: The Zn2Cys6-type transcription factor LeuB cross-links regulation of leucine biosynthesis and iron acquisition in Aspergillus fumigatus. PLoS Genet. 2018 Oct 26;14(10):e1007762. doi: 10.1371/journal.pgen.1007762.
Petzer V, Theurl I, Weiss G.: Established and Emerging Concepts to Treat Imbalances of Iron Homeostasis in Inflammatory Diseases.
Pharmaceuticals (Basel). 2018 Dec 11;11(4):135. doi: 10.3390/ph11040135.Posch W, Blatzer M, Wilflingseder D, Lass-Flörl C.: Aspergillus terreus: Novel lessons learned on amphotericin B resistance. Med Mycol. 2018 Apr 1;56(suppl_1):73-82. doi: 10.1093/mmy/myx119.
Schiela B, Bernklau S, Malekshahi Z, Deutschmann D, Koske I, Banki Z, Thielens NM, Würzner R, Speth C, Weiss G, Stiasny K, Steinmann E, Stoiber H.: Active Human Complement Reduces the Zika Virus Load via Formation of the Membrane-Attack Complex.
Front Immunol. 2018 Oct 17;9:2177. doi: 10.3389/fimmu.2018.02177.
Publications 2017:
Asshoff M, Petzer V, Warr M R, Haschka D, Tymoszuk P, Demetz E, Seifert M, Posch W, Nairz M, Maciejewski P, Fowles P, Burns C J, Smith G, Wagner K-U, Weiss G, Whitney J A, Theurl I.: Momelotinib inhibits ACVR1/ALK2, decreases hepcidin production and ameliorates anemia of chronic disease in rodents.
Bloodjournal (prepublished version). doi: 10.1182/blood-2016-09-740092.Orasch T, Prattes J, Faserl K, Eigl S, Düttmann W, Linder H, Haas H, Hoenigl M.: Bronchoalveolar lavage triacetylfusarinine C (TAFC) determination for diagnosis of invasive pulmonary aspergillosis in patients with hematological malignancies. Journal of Infection. doi: http://dx.doi.org/10.1016/j.jinf.2017.05.014.
Pangrazzi L, Naismith E, Meryk A, Keller M, Jenewein B, Trieb K, Grubeck-Loebenstein B.: Increased IL-15 Production and Accumulation of Highly Differentiated CD8+ Effector/Memory T Cells in the Bone Marrow of Persons with Cytomegalovirus.
Frontiers Immunology 8:715. https://doi.org/10.3389/fimmu.2017.00715. Volani C, Caprioli G, Calderisi G, Sigurdsson BB, Rainer J, Gentilini l, Hicks AA, Pramstaller PP, Weiss G, Smarason SV, Paglia G.: Pre-analytic evaluation of volumetric absorptive microsampling and integration in a mass spectrometry-based metabolomics workflow. Anal Bioanal Chem. 2017 Aug 17. doi: 10.1007/s00216-017-0571-8.
Nairz M, Schroll A, Haschka D, Dichtl S, Tymoszuk P, Demetz E, Moser P, Haas H, Fang F C, Theurl I, Weiss G.: Genetic and Dietary Iron Overload Differentially Affect the Course of Salmonella Typhimurium Infection.
Front. Cell. Infect. Microbiol. 7:110. doi: 10.3389/fcimb.2017.00110.Chandorkar P, Posch W, Zaderer V, Blatzer M, Steger M, Ammann CG, Binder U, Hermann M, Hörtnagl P, Lass-Flörl C, Wilflingseder D.: Fast-track development of an in vitro 3D lung/immune cell model to study Aspergillus infections. Scientific Reports. 7:11644. DOI:10.1038/s41598-017-11271-4.
Wu A, Tymoszuk P, Haschka D, Heeke S, Dichtl S, Petzer V, Seifert M, Hilbe R, Sopper S, Talasz H, Bumann D, Lass-Flörl C, Theurl I, Zhang K, Weiss G.: Salmonella utilizes zinc to subvert anti-microbial host defense of macrophages via modulation of NF-kB signaling.
Infect Immun. 2017 Sep 5. doi: 10.1128/IAI.00418-17.Volani C, Doerrier C, Demetz E, Haschka D, Paglia G, Lavdas AA, Gnaiger E, Weiss G.: Dietary iron loading negatively affects liver mitochondrial function. Metallomics. 2017 Nov 15;9(11):1634-1644. doi: 10.1039/c7mt00177k.
Brini I, Guerrero A, Hannachi N, Bouguila J, Orth-Höller D, Bouhlel A, Boughamoura L, Hetzer B, Borena W, Schiela B, Von Laer D, Boukadida J, Stoiber H.: Epidemiology and clinical profile of pathogens responsible for the hospitalization of children in Sousse area, Tunisia.
PLoS One. doi: 10.1371/journal.pone.0188325.Nairz M, Haschka D, Dichtl S, Sonnweber T, Schroll A, Aßhoff M, Mindur JE, Moser PL, Wolf D, Swirski FK, Theurl I, Cerami A, Brines M, Weiss G.: Cibinetide dampens innate immune cell functions thus ameliorating the course of experimental colitis. Scientific Reports. doi: 10.1038/s41598-017-13046-3.
Fabritius C, Ritschl PV, Resch T, Roth M, Ebner S, Günther J, Mellitzer V, Nguyen AV, Pratschke J, Sauter M, Klingel K, Kotsch K.: Deletion of the activating NK cell receptor NKG2D accelerates rejection of cardiac allografts.
American Journal of Transplantation 17(12). doi: 10.1111/ajt.14467.Sass G, Nazik H, Penner J, Shah H, Ansari SR, Clemons KV, Groleau MC, Dietl AM, Visca P, Haas H, Déziel E, Stevens DA.: Studies of Pseudomonas aeruginosa Mutants Indicate Pyoverdine as the Central Factor in Inhibition of Aspergillus fumigatus Biofilm. Journal of Bacteriology 200(1). doi: 10.1128/JB.00345-17.
Publications 2016:
Grasse M, Meryk A, Schirmer M, Grubeck-Loebenstein B, Weinberger B.: Booster vaccination against tetanus and diphtheria: insufficient protection against diphtheria in young and elderly adults.
Immunity & Ageing 13:26. doi: 10.1186/s12979-016-0081-0.Dietl A-M, Amich J, Leal S, Beckmann N, Binder U, Beilhack A, Pearlman E, Haas H.: Histidine biosynthesis plays a crucial role in metal homeostasis and virulence of Aspergillus fumigatus. Virulence 7(4):465-476. doi: 10.1080/21505594.2016.1146848.
Riedl M, Hofer J, Giner T, Rosales A, Häffner K, Simonetti GD, Walden U, Maier T, Heininger D, Jeller V, Weiss G, van den Heuvel L, Zimmerhackl LB, Würzner R, Jungraithmayr TC.: Novel biomarker and easy to perform ELISA for monitoring complement inhibition in patients with atypical hemolytic uremic syndrome treated with eculizumab.
J Immunol Methods 435:60-7. doi: 10.1016/j.jim.2016.05.009.Yaakov D B, Rivkin A, Mircus G, Albert N, Dietl A-M, Kovalerchick D, Carmeli S, Haas H, Kontoyiannis D P, Osherov N.: Identification and characterization of haemofungin, a novel antifungal compound that inhibits the final step of haem biosynthesis. J Antimicrob Chemother 71:946-952. doi:10.1093/jac/dkv446.
Pangrazzi L, Meryk A, Naismith E, Koziel R, Lair J, Krismer M, Trieb K, Grubeck-Loebenstein B.: "Inflamm-aging" influences immune cell survival factors in human bone marrow.
Eur J Immunol. doi: 10.1002/eji.201646570.Aigner M, Chandorkar P, Mutschlechner W, Lass-Flörl C.: Isavuconazole: an orphan drug for treating invasive candidiasis. Exp Opin Orphan Drug 4:333-342. doi: 10.1517/21678707.2016.1135048.
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horos@i-med.ac.at
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Vahedi-Shahandashti R, Houbraken J, Birch M, Lass-Flörl C.
